True or False? Question regarding proteins embedded in cell membranes!?

The integrity of a biomembrane would have to be disrupted in order to remove a lipid-anchored protein.





True or False?








Thanks in advance guys! Oh, and can you provide a quick explanation so I can learn something from this?True or False? Question regarding proteins embedded in cell membranes!?
I vote for true. There are two types of membrane associated proteins; integral and periphreal. I'm not sure what it means by ';lipid-anchored'; as this could be something spanning the membrane (integral) but attached to nearby lipids, or it could mean a protein attached on the outside/inside of the cell.





I know that for normal protein isolation, the membrane is disturbed using detergents (distrupts lipids). The protein is then isolated using various techniques, such as treating with polar-discriminating substances or (one of my favorites) treating with protein specific antibodies attached to heavy beads.





WesTrue or False? Question regarding proteins embedded in cell membranes!?
I vote for true, too.





I would assume that, by ';lipid-anchored';, you mean it's embedded in the cell membrane's nonpolar region and kept in place by repulsive forces from the membrane's polar regions. Therefore, without removing or temporarily disturbing the membrane's integrity by chemical or physical means, the repulsive polar region will prevent the lipid-anchored protein from being removed.
False. You can't disrupt the integrity of a cell membrane since integral membrane proteins are permanent. Therefore, you can remove a lipid-anchored protein without disrupting the bio-membrane's integrity.